abstract：:The acute biological activity of a homologous series of perfluorinated carboxylic acids - perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) - was studied. To analyze the potential risk of the perfluorinated ac...

journal_title：Environmental toxicology and pharmacology

authors： Mulkiewicz E,Jastorff B,Składanowski AC,Kleszczyński K,Stepnowski P

更新日期：2007-05-01 00:00:00

abstract：:The Cd has been recognized as one of the most toxic environmental and industrial pollutants due to its ability to induce disturbances in several organs and tissues following either acute or chronic exposure. This review accounts for the recent evidence on its mechanisms to induce neurotoxicity, the role of the blood-b...

journal_title：Environmental toxicology and pharmacology

authors： Méndez-Armenta M,Ríos C

更新日期：2007-05-01 00:00:00

abstract：:It is well known that developmental exposure to polychlorinated biphenyls (PCBs) could cause learning and memory deficits, but the underlying mechanisms are not clear. Actin cytoskeleton is directly involved in synaptic plasticity which is considered critical to learning and memory formation by LIM kinase 1 (LIMK-1)/c...

journal_title：Environmental toxicology and pharmacology

authors： Tang F,Yan C,Wu S,Li F,Yu Y,Gao Y,Jin X,Shen X

更新日期：2007-03-01 00:00:00

abstract：:Tinospora cordifolia (Guduchi) has been used for centuries for treating various ailments including cancer in Ayurvedic system of medicine. In this study, we report the mechanism of cell death exhibited by the hexane extract fraction of T. cordifolia (TcHf) against Ehrlich ascites tumor (EAT) in mice. Treatment of EAT ...

journal_title：Environmental toxicology and pharmacology

authors： Thippeswamy G,Salimath BP

更新日期：2007-03-01 00:00:00

abstract：:Adult mallard ducks and northern bobwhite quail were exposed to 0, 10, 50, or 150mg perfluorooctane sulfonate (PFOS)/kg in the diet for up to 21 weeks. Adult health, body and liver weight, feed consumption, gross morphology and histology of body organs, and reproduction were examined. Due to mortality, birds exposed t...

journal_title：Environmental toxicology and pharmacology

authors： Newsted JL,Coady KK,Beach SA,Butenhoff JL,Gallagher S,Giesy JP

更新日期：2007-01-01 00:00:00

abstract：:Cannabis and Mandrax abuse is unique to South Africa; and most research has focused on the socio-economic impact rather than the adverse effects on the developing brain. Therefore, the aim of this study is to determine the effects of Mandrax and Cannabis alone and in combination on the developing brain by using primar...

journal_title：Environmental toxicology and pharmacology

authors： da Silva AA,Bester MJ,Pretorius E

更新日期：2007-01-01 00:00:00

abstract：:The purpose of the present study was to assess do selected pesticides as well as their binary combinations act as inhibitors of P-glycoprotein (P-gp) activity of NIH 3T3 mouse fibroblasts stably transfected with human MDR1 gene (NIH 3T3/MDR1). As a result of P-gp inhibition, the increase of intracellular accumulation ...

journal_title：Environmental toxicology and pharmacology

authors： Pivčević B,Zaja R

更新日期：2006-11-01 00:00:00

abstract：:Mitochondria play a pivotal role in apoptosis of mammalian cells by releasing apoptogenic proteins such as cytochrome c into the cytoplasm. Mitochondrial membrane permeability during apoptosis is regulated directly by the Bcl-2 family of proteins. In glioma cells, there are no specific features of apoptosis compared w...

journal_title：Environmental toxicology and pharmacology

authors： Jin UH,Lee DY,Kim DS,Lee IS,Kim CH

更新日期：2006-09-01 00:00:00

abstract：:The histopathological effects of deltamethrin on the gill and kidney tissues of the common carp, Cyprinus carpio were determined by light microscopy. The fish were exposed to 0.029mgl(-1) (50% of 96h LC(50)) and 0.041mgl(-1) (70% of 96h LC(50)) solutions of deltamethrin for short-term (96h). The most common gill chang...

journal_title：Environmental toxicology and pharmacology

authors： Cengiz EI

更新日期：2006-09-01 00:00:00

abstract：:The effect of the Vitamin E model compound Trolox in reactions with Cr(VI) in the presence or absence of hydrogen peroxide was investigated. The aim of this study was to establish and discuss potential Trolox-mediated pro-oxidative reactions. The importance of the Trolox:Cr(VI) ratio in the Cr(VI) reduction process wa...

journal_title：Environmental toxicology and pharmacology

authors： Poljšak B,Gazdag Z,Pesti M,Jenko-Brinovec S,Belagyi J,Plesničar S,Raspor P

更新日期：2006-07-01 00:00:00

abstract：:It is well established that oxidative stress plays a central role in the onset and progression of over a 100 different diseases. Recently, a growing body of evidence has shown that chemicals/agents as diverse as aromatic compounds, UV radiation and redox-active metals also generate oxy-radicals in vivo and lead to cel...

journal_title：Environmental toxicology and pharmacology

authors： Ashraf SS,Galadari S,Patel M

更新日期：2006-07-01 00:00:00

abstract：:Chlorinated derivatives of bisphenol A (ClBPAs) have been detected in wastewater from waste paper recycling plants. BPA and ClBPAs are always exposed to ultraviolet (UV) radiation in the environment and consequently various photoproducts might be produced. Acute cytotoxicity of photoproducts of BPA and ClBPAs are not ...

journal_title：Environmental toxicology and pharmacology

authors： Mutou Y,Ibuki Y,Terao Y,Kojima S,Goto R

更新日期：2006-05-01 00:00:00

abstract：:Drug-induced blood dyscrasias can be either acute and predictable or delayed and unpredictable (idiosyncratic). The predictable toxicity is relatively easy to reproduce with in vitro models, although they may not work for drugs that require bioactivation. It is very unlikely that idiosyncratic blood dyscrasias can be ...

journal_title：Environmental toxicology and pharmacology

authors： Ip J,Uetrecht JP

更新日期：2006-02-01 00:00:00

abstract：:The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are m...

journal_title：Environmental toxicology and pharmacology

authors： Wormstone IM,Collison DJ,Hansom SP,Duncan G

更新日期：2006-02-01 00:00:00

abstract：:The aims of the present study were to verify the suitability of short-term in situ test with the neotropical fish Prochilodus lineatus and to evaluate from a set of biochemical and physiological biomarkers the ones which could work as sensitivity tools for the environmental quality assessment. In situ tests were carri...

journal_title：Environmental toxicology and pharmacology

authors： Camargo MM,Martinez CB

更新日期：2006-01-01 00:00:00

abstract：:One purpose in this research was to determine the toxic effects of Cd on antioxidant enzymes of Oxya chinensis (Orthoptera: Acridoidae). Changes in the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and guaiacol peroxidase (GPx) were measured in O. chinensis insects injected with Cd(...

journal_title：Environmental toxicology and pharmacology

authors： Lijun L,Xuemei L,Yaping G,Enbo M

更新日期：2005-11-01 00:00:00

abstract：:Using the European common frog, Rana temporaria, as a model, we have studied the organ-specific gene expression patterns of thyroid hormone receptor isoforms after exposure to an organochlorine (OC) compound, p,p'-DDE. Four groups of frogs were subcutaneously injected with p,p'-DDE at 0.01, 0.1, 1 and 10mg/kg body wei...

journal_title：Environmental toxicology and pharmacology

authors： Arukwe A,Jenssen BM

更新日期：2005-11-01 00:00:00

abstract：:Ozonation and chlorination of 17β-estradiol (E2), 17α-ethynylestradiol (EE2), bisphenol A (BPA), and nonylphenol (NP) were performed to evaluate the estrogenic activity of the by-products of these endocrine disrupting chemicals (EDCs). After 15min oxidation, samples were extracted using solid phase extraction (SPE) ca...

journal_title：Environmental toxicology and pharmacology

authors： Liu J,Carr S,Rinaldi K,Chandler W

更新日期：2005-09-01 00:00:00

abstract：:Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenes...

journal_title：Environmental toxicology and pharmacology

authors： Anbarasi K,Sabitha KE,Devi CS

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:: Coughing is one of the chronic respiratory symptoms of patients exposed to sulfur mustard (SM) used against Iranian combatants and civilians by Iraq during the Iran-Iraq war, between 1983 and 1989. This study carried out on SM exposed patients who referred to our clinic because of exacerbation of chronic c...

journal_title：Environmental toxicology and pharmacology

authors： Ghanei M,Hosseini AR,Arabbaferani Z,Shahkarami E

更新日期：2005-07-01 00:00:00

abstract：:Trichosanthin (TCS) is a type 1 ribosome inactivating protein extracted from Chinese medicinal herb. It possesses various biological functions such as abortifacient, anti-tumor and anti-viral activities. Clinical trial of this compound against human immunodeficiency virus (HIV) had been conducted. However, its use is ...

journal_title：Environmental toxicology and pharmacology

authors： Chan HM,Tam SC

更新日期：2005-07-01 00:00:00

abstract：:The dominant lethal assay was utilized to assess the reproductive performance in male mice, possible genetic hazards, and persistent damage of aluminum (Al). Al chloride, AlCl(3), was administered subcutaneously to CD-1 adult male mice at dosages of 0, 7, or 13mg Al/kg body weight/day for 2 weeks of pre-mating periods...

journal_title：Environmental toxicology and pharmacology

authors： Guo CH,Lu YF,Hsu GS

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:: To investigate the exposure to terephthalic acid (TPA), and to evaluate it's effects on organ function including the potential risk factors for uroliths and bladder tumor to TPA. METHODS:: Exposure-response modeling was carried out in a cohort of 141 TPA exposure workers and three subgroups were classifie...

journal_title：Environmental toxicology and pharmacology

authors： Dai G,Cui L,Song L,Gong N,Chen J,Zhao R,Wang S,Chang HC,Wang X

更新日期：2005-07-01 00:00:00

abstract：:The Tokyo subway sarin attack was the second documented incident of nerve gas poisoning in Japan. The St. Luke's International Hospital received 640 patients on the day of the attack. Reduction in plasma cholinesterase (ChE) activity was generally associated with the severity of acute signs of toxicity. With time and ...

journal_title：Environmental toxicology and pharmacology

authors： Okumura T,Hisaoka T,Naito T,Isonuma H,Okumura S,Miura K,Maekawa H,Ishimatsu S,Takasu N,Suzuki K

更新日期：2005-05-01 00:00:00

abstract：:Styrene exposure and color vision for 108 workers (21-65 years) was studied at Swedish reinforced plastic plants. Acute exposure was measured at work. Data on past exposures and personal background data were collected by questionnaire. Current exposure varied between 0.3 and 96mg/m(3). Cumulative past exposures varied...

journal_title：Environmental toxicology and pharmacology

authors： Iregren A,Johnson AC,Nylén P

更新日期：2005-05-01 00:00:00

abstract：:Although airborne chemicals can directly elicit adverse reactions via stimulation of the olfactory and trigeminal nerves, such as sensory irritation of the mucous membranes of the eyes, nose and throat, an individual's subjective experience is often the result of a complex sequence of events involving those sensory, p...

journal_title：Environmental toxicology and pharmacology

authors： Smeets MA,Dalton PH

更新日期：2005-05-01 00:00:00

abstract：:The Pupillographic Sleepiness Test (PST) is a new neurophysiological method to assess sleepiness. In an exposure study to a constant exposure level of 50ppm toluene on 20 healthy men, our aim was to find out, if increased sleepiness could be seen with PST. PST was performed before and after 4.5h of exposure. General c...

journal_title：Environmental toxicology and pharmacology

authors： Muttray A,Spelmeyer U,Hommel G,Oesch F,Jung D,Rose DM,Mayer-Popken O,Rossbach B,Letzel S

更新日期：2005-05-01 00:00:00

abstract：:To address the growing need for scientifically valid and humane alternatives to developmental neurotoxicity testing (DNT), we propose that basic research scientists in developmental neurobiology be brought together with mechanistic toxicologists and policy analysts to develop the science and policy for DNT alternative...

journal_title：Environmental toxicology and pharmacology

authors： Lein P,Silbergeld E,Locke P,Goldberg AM

更新日期：2005-05-01 00:00:00

abstract：:Effects of aluminum (Al) on membrane properties of excitable cells are not fully understood. Several reports have identified cellular membranes as sensitive targets for Al intoxication. In the present study, we tested the hypothesis that treatment with Al would alter membrane fluidity and potential and these changes w...

journal_title：Environmental toxicology and pharmacology

authors： Johnson VJ,Tsunoda M,Murray TF,Sharma RP

更新日期：2005-02-01 00:00:00

abstract：:Epidemiological studies indicate that arsenic exposure induces hypertension. We hypothesized that arsenate exposure modulates the contractility of vascular smooth muscle through the stress response. Intraperitoneal injection of sodium arsenate (15mg/kg) 16h before increased not only the blood pressure of rats but also...

journal_title：Environmental toxicology and pharmacology

authors： Park TG,Seong Y,Suk K,Ha JH,Kim I

更新日期：2005-02-01 00:00:00

abstract：:Biological effects of waste water samples were investigated using the method for isometric contraction measurements that is widely employed in the medical field for studying the effects of various drugs on heart and smooth muscle preparations. Raw waste water samples from a municipal treatment plant were extracted wit...

journal_title：Environmental toxicology and pharmacology

authors： Fuerhacker M,Lemmens-Gruber R,Studenik CR

更新日期：2005-02-01 00:00:00

abstract：:Excessive nitric oxide (NO) production in mice serum and testis due to aluminum (Al) exposure has been shown in previous studies. The aim of this study was to further investigate the role of NO on aluminum-suppressed testosterone level in male CD-1 mice. Each animal in six groups, was given intraperitoneal injections ...

journal_title：Environmental toxicology and pharmacology

authors： Guo CH,Lin CY,Yeh MS,Hsu GS

更新日期：2005-01-01 00:00:00

abstract：:A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon f...

journal_title：Environmental toxicology and pharmacology

authors： Koski P,Bäckman C,Pelkonen O

更新日期：2005-01-01 00:00:00

abstract：:In order to better inform scientific decision making in the occupational environment, we need a better understanding of the toxicology of mixed exposures. In particular, we need an understanding of the dose-response relationship from the level of individual or population exposure down to the molecular level (and then ...

journal_title：Environmental toxicology and pharmacology

authors： Robinson P,Macdonell M

更新日期：2004-12-01 00:00:00

abstract：:The protection of human health from the adverse effects of cumulative environmental exposure to chemical mixtures is an important issue. Of particular interest is the detection and characterization of interaction among chemicals in complex mixtures. Response surface methodology, often supported by factorial designs, i...

journal_title：Environmental toxicology and pharmacology

authors： Gennings C,Carter WH Jr,Casey M,Moser V,Carchman R,Simmons JE

更新日期：2004-11-01 00:00:00

abstract：:The effects of bis(2-ethylhexyl) phthalate (DEHP), γ-hexachlorocyclohexane (γ-HCH), and 17β-estradiol (E2) on the fry stage of medaka were investigated. The medaka fry were exposed to different concentrations (0.01, 0.1, 1, and 10μg/L) of these chemicals for 3 weeks after hatching. Then, mortality, body weight, sex ra...

journal_title：Environmental toxicology and pharmacology

authors： Chikae M,Ikeda R,Hatano Y,Hasan Q,Morita Y,Tamiya E

更新日期：2004-09-01 00:00:00

abstract：:Genistein receives much attention because of its potential to prevent hormone-related cancer and cardiovascular diseases. Limited information is available on the pharmacokinetics of this compound like, for instance, their intestinal uptake by humans and systematic bioavailability. In this study, the fate of the absorp...

journal_title：Environmental toxicology and pharmacology

authors： Steensma A,Bienenmann-Ploum ME,Noteborn HP

更新日期：2004-06-01 00:00:00

abstract：:The effects of oral administration of tamoxifen, 17α-ethynylestradiol (EE2), flutamide, and methyltestosterone (MT), on plasma vitellogenin levels of male and female medaka were investigated. Medaka were fed diets containing different concentrations of these chemicals for 7 days, and these plasma vitellogenin levels w...

journal_title：Environmental toxicology and pharmacology

authors： Chikae M,Ikeda R,Hasan Q,Morita Y,Tamiya E

更新日期：2004-05-01 00:00:00

abstract：:Effects of two widely found chemical pollutants, bis(2-ethylhexyl) phthalate (DEHP) and benzo[a]pyrene (BaP), on the embryos of Japanese medaka were investigated. The embryos were exposed to different concentrations (0.01, 0.1, 1, and 10μg/l) of DEHP and BaP. The following were investigated: (1) hatching time and hatc...

journal_title：Environmental toxicology and pharmacology

authors： Chikae M,Hatano Y,Ikeda R,Morita Y,Hasan Q,Tamiya E

更新日期：2004-04-01 00:00:00

abstract：:Single-chemical and mixture concentration-response curves generated using a frog embryo model were examined for value in assessing whether chemicals exert toxic effects at the same or at different molecular sites of action. Toxicity tests were conducted on a series of osteolathyrogens, i.e. chemicals that inhibit cros...

journal_title：Environmental toxicology and pharmacology

authors： Dawson DA,Scott BD,Ellenberger MJ,Pöch G,Rinaldi AC

更新日期：2004-03-01 00:00:00